Aspergillus niger

The release of the genome sequences of two strains of Aspergillus niger has allowed systems-level investigations of this important microbial cell factory. To this end, tools for doing data integration of multi-ome data are necessary, and especially interesting in the context of metabolism. On the basis of an A. niger bibliome survey, we present the largest model reconstruction of a metabolic network reported for a fungal species. The reconstructed gapless metabolic network is based on the reportings of 371 articles and comprises 1190 biochemically unique reactions and 871 ORFs. Inclusion of isoenzymes increases the total number of reactions to 2240(1).

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Aspergillus niger model

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Citations
1) M. R. Andersen; M. L. Nielsen; J. Nielsen (2008) Metabolic model integration of the bibliome, genome, metabolome and reactome of Aspergillus niger Mol. Systems Biol. 4:178
A * indicates that these authors contributed equally to the work.